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The tissue adhesive Histoacryl® consists of monomeric n-butyl-2-cyanoacrylate, which polymerises quickly in connection with tissue fluid. Histoacryl® is available in two colours: translucent, special for facial application, and blue, which enables an easy control over the quantity applied in different indications approved.
- Wound closure in one minute [1, 2, 3, 4]
- Significant less pain than suture materials 
- Effective microbial barrier [6, 7, 8]
- Storage at room temperature <22º 
- High level of patient and physician satisfaction [2, 7, 10, 11, 12]
- Save time and costs [1, 2, 3, 4, 5, 10, 12]
- Only one layer is needed [4, 8]
- Histoacryl® can be used for closure of endoscopic incisions [8, 13]
- For bleeding and non-bleeding varices [14, 15, 16, 17, 18, 19]
- Combined therapy with Histoacryl® and conventional sclerosation therapy is possible] [14, 15, 17, 20]
- Final hemostasis is achieved in >90% of cases [14, 15, 16, 17, 18, 19]
- Lower rebleeding rate than with band ligation [14, 15, 18, 20]
- Non-invasive method reported to be better tolerated by the patient than traditional fixation methods [22, 23, 24, 25, 26]
- Stand-alone fixation method in different hernia repair techniques [22, 23, 24, 25, 26]
- Comparable recurrence rate than with traditional fixation methods [23, 24, 25, 26]
- Low intra- and postoperative morbidity [24, 26]
- Reduced risk of post-operative chronic pain compared to traditional fixation methods [23, 24, 25, 26]
- Decreased surgery time compared to traditional fixation methods [23, 25]
- Good biocompatibility and in vivo tolerance [23, 24, 25, 26, 27]
- Skin Closure: Closure of skin wounds without tension (including clean surgical incisions and incisions from minimally invasive surgery), and simple, thoroughly cleansed, trauma-induced lacerations.
- Sclerotherapy: Sclerotherapy of large oesophageal or fundal varices.
- Mesh fixation: Fixation of hernia meshes, especially in inguinal hernia surgery.
•  Dumville JC, Coulthard P, Worthington HV, Riley P, Patel N, Darcey J, Esposito M, van der Elst M, van Waes OJ. Tissue adhesives for closure of surgical incisions. Cochrane Database Syst Rev. (2014) Nov 28;(11)
•  Koonce SL, Eck DL, Shaddix KK, Perdikis G. A prospective randomized controlled trial comparing N-butyl-2 cyanoacrylate (Histoacryl), octyl cyanoacrylate (Dermabond), and subcuticular suture for closure of surgical incisions. Ann Plast Surg. (2015) 74:1 (107-10).
•  Lloris-Carsí JM, Ballester-Álvaro J, Barrios C, Zaragozá-Fernández C, Gómez-De la Cruz C, González-Cuartero C, Prieto-Moure B, Cejalvo-Lapeña D. Randomized clinical trial of a new cyanoacrylate flexible tissue adhesive (Adhflex) for repairing surgical wounds. Wound Repair Regen. (2016) 24:3 (568-80).
•  Elmasalme FN, Matbouli SA, Zuberi MS. Use of tissue adhesive in the closure of small incisions and lacerations. J Pediatr Surg. (1995) 30:6 (837-8).
•  Farion K, Osmond MH, Hartling L, Russell K, Klassen T, Crumley E, Wiebe N. Tissue adhesives for traumatic lacerations in children and adults. Cochrane Database Syst Rev. (2002) 3:CD003326
•  mdt medical device testing GmbH report / Project 12m020 / Determination of Microbiological Barrier Properties of Two Topical Skin Adhesives.
•  Ranson JM, et al. Haemostatic property of cyanoacrylate in pedicled flaps. Br J Oral Maxillofac Surg (2016), http://dx.doi.org/10.1016/j.bjoms.2016.01.035
•  Yulevich A, Cohen Z, Mares AJ. Use of N-Butyl-2-Cyanoacrylate (HistoacrylR) in Closure of Thoracoscopic an Laparoscopic Surgical Wounds in Children. Pediatric Endosurg. (1998) 2:1 (31-4).
•  Long Time Stability: RDR/DID/CHM/SLE/17095 Long time stability at room temperature of Histoacryl in aluminum pouches_reissue
•  Hovaghimian DG, Sedira KAA, Farag MY. N-butyl-2-cyanoacrylate tissue adhesive versus subcuticular skin closure in external dacryocystorhinostomy. DJO (2015) 16 (97–102).
•  Edwards S, Parkinson L. Is Fixing Pediatric Nail Bed Injuries With Medical Adhesives as Effective as Suturing?: A Review of the Literature. Pediatr Emerg Care. (2016) Dec 12. [Epub ahead of print]
•  Goktas N, Karcioglu O, Coskun F, Karaduman S, Menderes A. Comparison of tissue adhesive and suturing in the repair of lacerations in the emergency department. Eur J Emerg Med. (2002) 9:2 (155-8).
•  13 Yang J., Yong Jin Na, Yong Jung Song, Ook Hwan Choi, Sun Kyung Lee, Hwi Gon Kim. The effectiveness of laparoendoscopic single-site surgery (LESS) compared with conventional laparoscopic surgery for ectopic pregnancy with hemoperitoneum. Taiwanese Journal of Obstetrics & Gynecology 55 (2016) 35e39
•  Cho E., Jun C.H., Cho S.B., Park C.H., Kim H.S., Choi S.K., Rew J.S. Endoscopic variceal ligation-induced ulcer bleeding: What are the risk factors and treatment strategies? Medicine (United States) (2017) 96:24 Article Number e7157
•  Holster IL, Tjwa ET, Moelker A, Wils A, Hansen BE, Vermeijden JR, Scholten P, van Hoek B, Nicolai JJ, Kuipers EJ, Pattynama PM, van Buuren HR. Covered transjugular intrahepatic portosystemic shunt versus endoscopic therapy + β-blocker for prevention of variceal rebleeding. Hepatology. (2016) 63:2 (581-9).
•  Kozieł S, Kobryń K, Paluszkiewicz R, Krawczyk M, Wróblewski T. Endoscopic treatment of gastric varices bleeding with the use of n-butyl-2 cyanoacrylate. Prz Gastroenterol (2015) 10:4 (239–243).
•  Jang WS, Shin HP, Lee JI, Joo KR, Cha JM, Jeon JW, Lim JU. Proton pump inhibitor administration delays rebleeding after endoscopic gastric variceal obturation. World journal of Gastroenterology (2014) 20:45 (17127-17131).
•  Prachayakul V, Aswakul P, Chantarojanasiri T, Leelakusolvong S. Factors influencing clinical outcomes of Histoacrylglue injection-treated gastric variceal hemorrhage. World J Gastroenterol. (2013) 19:15 (2379–2387).
•  Lo GH, Lin CW, Perng DS, Chang CY, Lee CT, Hsu CY, Wang HM, Lin HC. A retrospective comparative study of histoacryl injection and banding ligation in the treatment of acute type 1 gastric variceal hemorrhage. Scand J Gastroenterol. (2013) 48:10 (1198-204).
•  Feretis C, Dimopoulos C, Benakis P, Kalliakmanis B, Apostolidis N. N-butyl-2-cyanoacrylate (Histoacryl) plus sclerotherapy versus sclerotherapy alone in the treatment of bleeding esophageal varices: a randomized prospective study. Endoscopy. (1995) 27:5 (355-7).
•  Tan PC, Hou MC, Lin HC, Liu TT, Lee FY, Chang FY, Lee SD. A randomized trial of endoscopic treatment of acute gastric variceal hemorrhage: N-butyl-2-cyanoacrylate injection versus band ligation. Hepatology. (2006) 43:4 (690-7).
•  Liew W, Wai YY, Kosai NR, Gendeh HS. Tackers versus glue mesh fixation: an objective assessment of postoperative acute and chronic pain using inflammatory markers. Hernia. (2017) 21:4 (549-554).
•  Hoyuela C, Juvany M, Carvajal F, Veres A, Troyano D, Trias M, Martrat A, Ardid J, Obiols J, López-Cano M. Randomized clinical trial of mesh fixation with glue or sutures for Lichtenstein hernia repair. Br J Surg. (2017) 104:6 (688-694).
•  Helbling C, Schlumpf R. Sutureless Lichtenstein: first results of a prospective randomized clinical trial. Hernia. (2003) 7:2 (80-4).
•  Kim-Fuchs C, Angst E, Vorburger S, Helbling C, Candinas D, Schlumpf R. Prospective randomized trial comparing sutured with sutureless mesh fixation for Lichtenstein hernia repair: long-term results. Hernia. (2012) 16:1 (21-7).
•  Testini M, Lissidini G, Poli E, Gurrado A, Lardo D, Piccinni G. A singlesurgeon randomized trial comparing sutures, N-butyl-2-cyanoacrylate and human fibrin glue for mesh fixation during primary inguinal hernia repair. Can J Surg. (2010) 53:3 (155-60
•  Kukleta JF, Freytag C, Weber M. Efficiency and safety of mesh fixation in laparoscopic inguinal hernia repair using n-butyl cyanoacrylate: long-term biocompatibility in over 1,300 mesh fixations. Hernia. (2012) 16:2 (153–62).